Identifying the underlying cause of cardiac dysfunction is essential for determining the appropriate treatment and prognosis. The current management paradigm for heart failure (HF) and cardiomyopathies predominantly emphasizes structural and ischemic etiologies, often overlooking the substantial role of electrical dyssynchrony in cardiac dysfunction and remodeling. This work introduces a novel conceptual framework that integrates existing evidence illustrating how electrical dyssynchrony induces mechanical dyssynchrony, culminating in regional cardiac impairment and structural remodeling. The myocardial area that activated early lacks proper afterload, impairing its ability to perform work effectively. Consequently, disuse atrophy gradually manifests in the early a ctivation area over time. We propose the concept of early-excitation segment atrophy (EESA) syndrome to address the HF caused by asynchronous conduction. For the left ventricle, whichever part contracts first will become disused and may contribute to or exacerbate HF. The conduction abnormalities known to induce EESA include left bundle branch block (LBBB), right ventricular pacing (RVP), bilateral bundle branch block (BBBB), Wolff–Parkinson–White (WPW) syndrome, and premature ventricular contractions (PVCs). Appropriate diagnosis and treatment will lead to improved left ventricular ejection fraction and reduced mortality. By integrating EESA into clinical practice, we aim to improve the recognition and
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