In this study, the effect of Moringa oleifera extracts were inves tigated on an immunosuppressed model of cyclophosphamideinduced Swiss mice. M. oleifera seed and root extracts (2.0 g kg−1 body wt) were administered orally for 7 consecutive days; cyclo phosphamide (CP) (200 mg kg−1 i.p.) was administered by IV on the 4th day. Results indicated that the extracts of the M. oleifera seeds and roots ameliorated the immunosuppressive effects of CP on delayed type hypersensitivity (DTH) response, leukocyte counts, relative organ weight, IgM concentration, serum TNF-α assay and micro-histological images. This study demonstrated in vivo the therapeutic effect of M. oleifera on the immune response in clinical application. ARTICLE HISTORY Received 3 May 2020 KEYW ORDS Bioactivity; immunostimulatory activity; immunosuppression; Swiss mice Introduction There is a growing interest in using natural products to improve the immune response since many natural products have shown immunomodulatory effects and influence on the immune system of the human body.[1] Immunosuppression is a state where the body responds inadequately to pathogens and external organism, individuals who are immunocompromised are at higher risk of infec tion and cancer.[2] Immunosuppression can be due to the patient’s genetics disposition or due to external source such as radiation, drug or chemotherapy. Most of the synthetic prescription immunostimulants (e.g. Lonquex, Mepact) possess side effe
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